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That's something you never see any more, villains from one franchise battling a different hero or group of heroes.
There are so many great combonations.
Sinister Six vs Alpha Flight
Mr. Sinister vs Fantastic Four
Klaw and Friends vs Alpha Flight
Deadpool vs Spiderman
Emplate vs Alpha Flight
Dr. Doom vs Iron Man
Ultron vs Alpha Flight
etc...
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Klaw along with a few others against Alpha Flight. Yes like Backlash, Anaconda, Mr. Fear, Titana, maybe have someone like the Mandarin put together a team of villians to take on Alpha Flight.